MERORIGHT 500mg Powder for Injection
Therapeutic Class
Carbapenem antibiotic
Indications
Susceptible infections including intra abdominal infections, menigitis, respiratory tract infections, septicemia, skin infections, urinary tract infections and infections in immunocompromised patients
Chemical Composition
Each vial contains sterile meropenem trihydrate USP equivalent to anhydrous Meropenem 500mg and, sodium carbonate equivalent to sodium 45.1 mg
Packaging
1 vial/ Box
Dosage & Administration
The dosage and duration of therapy shall be established depending on type and severity of infection and the condition of the patient.The recommended daily dosage is as follows:500 mg IV every 8 hours in the treatment of pneumonia, UTI, gynaecological infections such as endometritis, skin and skin structure infections.1 g IV every 8 hours in the treatment of nosocomial pneumonias, peritonitis, and septicemia. In menigitis, the recommended dosage is 2g every 8 hours
Contraindications
Individuals with known hypersensitivity to the active substance or to any of the excipients used in the formulation.
Side Effects
Generally well tolerated. Side effect rarely require cessation of therapy and are generally mild and transient, serious side effects are rare.
Drug Interaction
Always tell your doctor if you are using or receiving any of the following medicines in addition to Meroright : 1.Probenecid inhibits the renal tubular secretion of meropenem, which can increase meropenem levels in the blood.2. Valproic Acid (Valproate): Meropenem can lower the blood levels of valproic acid, potentially leading to a reduction in its effectiveness in preventing seizures3. Other Antibiotics (e.g., Aminoglycosides): When meropenem is used in combination with other antibiotics, especially aminoglycosides (e.g., gentamicin), there is a potential for increased nephrotoxicity.4.Methotrexate: Although not a direct drug interaction, the use of meropenem with methotrexate could potentially increase the risk of toxicity due to the impact of meropenem on renal function, which may affect methotrexate clearance.5. Anticoagulants (e.g., Warfarin):There is some evidence that meropenem may slightly increase the anticoagulant effect of warfarin.