MERORIGHT 1g Powder for Injection

Therapeutic Class

Carbapenem antibiotic

Indications

Susceptible infections including intra abdominal infections, menigitis, respiratory tract infections, septicemia, skin infections, urinary tract infections and infections in immunocompromised patients

Chemical Composition

Each vial contains sterile meropenem trihydrate USP equivalent to anhydrous Meropenem 1gm and, sodium carbonate equivalent to sodium 90.2 mg

Packaging

1 vial/ Box

Dosage & Administration

The dosage and duration of therapy shall be established depending on type and severity of infection and the condition of the patient.The recommended daily dosage is as follows:500 mg IV every 8 hours in the treatment of pneumonia, UTI, gynaecological infections such as endometritis, skin and skin structure infections.1 g IV every 8 hours in the treatment of nosocomial pneumonias, peritonitis, and septicemia. In menigitis, the recommended dosage is 2g every 8 hours

Contraindications

Individuals with known hypersensitivity to the active substance or to any of the excipients used in the formulation.

Side Effects

Generally well tolerated. Side effect rarely require cessation of therapy and are generally mild and transient, serious side effects are rare.

Drug Interaction

Always tell your doctor if you are using or receiving any of the following medicines in addition to Meroright : 1.Probenecid inhibits the renal tubular secretion of meropenem, which can increase meropenem levels in the blood.2. Valproic Acid (Valproate): Meropenem can lower the blood levels of valproic acid, potentially leading to a reduction in its effectiveness in preventing seizures3. Other Antibiotics (e.g., Aminoglycosides): When meropenem is used in combination with other antibiotics, especially aminoglycosides (e.g., gentamicin), there is a potential for increased nephrotoxicity.4.Methotrexate: Although not a direct drug interaction, the use of meropenem with methotrexate could potentially increase the risk of toxicity due to the impact of meropenem on renal function, which may affect methotrexate clearance.5. Anticoagulants (e.g., Warfarin):There is some evidence that meropenem may slightly increase the anticoagulant effect of warfarin.